PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was (...) assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning and the trail making tests were the most frequent outcome assessment tools. All studies used regression as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments. (shrink)

Few thinkers have left such an influence across such a diverse range of studies as Michel Foucault has. This book pays homage to that diversity by presenting a multidisciplinary series of analyses dedicated to the question of power today.

_Riassunto_: Diversi studi hanno posto in risalto le affinità tra la filosofia critica di Wittgenstein e la psicoanalisi di Lacan. Questo lavoro passa in rassegna alcuni aspetti comuni ai due autori, delineando una prospettiva d’incontro teoretica e concettuale. Un punto d’incontro tra questi due pensatori comprende la fondamentale attenzione per il linguaggio e un atteggiamento critico verso la concettualizzazione classica della soggettività. Questo saggio tenta di sviluppare teoreticamente questi punti di contatto introducendo il concetto di soggettività senza interiorità, un soggetto (...) senza psicologia. In effetti, l’affidamento di Wittgenstein sulla grammatica e il ricorso di Lacan al significante portano allo stesso risultato: considerare il linguaggio in sé come matrice della soggettività. Da questa prospettiva la fondazione della soggettività non risiede più in una certa supposta sostanza metafisica bensì in una esteriorità radicale, nei giochi linguistici. _Parole chiave_: Wittgenstein; Lacan; Inconscio; Linguaggio; Grammatica _A subjectivity without interiority: Wittgenstein with Lacan_ _Abstract_: Several studies highlight affinities between Wittgenstein’s critical philosophy and Lacan’s psychoanalysis. The following article revisits certain points of both authors, proposing a theoretical and conceptual encounter between them. Indeed, the common ground between these two thinkers includes a fundamental focus on language and a critical approach to classic conceptualisation of subjectivity. This contribution attempts to theoretically developing this encounter by introducing the concept of subjectivity without interiority, a subject without psychology. In fact, Wittgenstein’s reliance on grammar and Lacan’s use of the signifier yield the same result: pointing to language itself as the matrix of subjectivity. From this perspective, the foundation of subjectivity no longer resides in some supposed metaphysical substance, but rather in a radical exteriority, in linguistic games. _Keywords_: Wittgenstein; Lacan; Unconscious; Language; Grammar. (shrink)

: Self-consciousness is considered in a framework comprising four dimensions which are theoretically defined and supported by clinical neuropsychological evidence. Self-monitoring is defined as the ability to reflect on one’s own behaviour, with supporting evidence for deficits in this capacity noted in anosognosia syndrome. Self-feeling is defined as the capacity to feel all sensations related to one’s own body, with supporting evidence from deficiencies occurring in alexithymia, psychosomatic states and Cotard’s delusion. Identity refers to the capacity to recognize an object (...) as identical to oneself, based on autobiographic memory; pathological conditions related to this dimension include delusions of identity and the Zelig syndrome. Ownership is the capacity to perceive the status of ones’ own body, and is clinically altered in somatoparaphrenia. All four dimensions are related to specific brain networks. Keywords: Self-Monitoring; Self-Feeling; Identity; Ownership; Neurocognitive Dimensions Le dimensioni neurocognitive dell’autocoscienza Riassunto: L’autocoscienza viene inquadrata in base a quattro dimensioni, determinate in via teorica e supportate da evidenze cliniche di carattere neuropsicologico. L’automonitoraggio è definito quale capacità di riflettere sul proprio comportamento ed è sostenuto da evidenze che derivano da quella sindrome denominata anosognosia. Il sentire il proprio sé è la capacità di avvertire tutte le sensazioni del corpo proprio ; questa dimensione è supportata da evidenze derivanti da condizioni cliniche quali l’alessitimia, le affezioni psicosomatiche e il delirio di Cotard. L’identità si riferisce alla capacità di riconoscere come identico a se stesso un oggetto, fondata sulla memoria autobiografica; le condizioni patologiche legate a questa dimensione sono il delirio di identità e la sindrome di Zelig. Il possesso di sé è la capacità di percepire lo stato del proprio corpo, condizione che risulta alterata nella somatoparafrenia. Tutte queste quattro dimensioni sono collegate a specifici network cerebrali. Parole chiave: Automonitoraggio; Sentimento di sé; Identità; Padronanza di sé; Dimensioni neurocognitive. (shrink)

In questo articolo si prendono in esame due Lares bronzei ritrovati negli scavi di Veleia, custoditi presso il locale Antiquarium. Le due statuette, molto diverse tra loro, presentano alcune peculiarità iconografiche: una sembra appartenere a una rara tipologia di Compitales con rhyton e kantharos; l’altra, vicina all’iconografia del Lar Familiaris, presenta gli attributi posti in posizione inversa. Nello studio si cerca di contestualizzare le due statuette nel panorama della piccola bronzistica della Cisalpina, e di approfondire le conoscenze relative a queste (...) due rare iconografie. (shrink)

Fino a una quindicina di anni fa, l’idea di una connessione forte tra l’estetica da una parte e l’intermedialità e l’interattività dall’altra non sarebbe stata probabilmente pensata nei termini in cui essa emerge nei contributi qui presentati. Di interattività si sarebbe presumibilmente parlato a partire dagli esperimenti di arte interattiva e di incontro tra arte e video: una forma di interazione tutta compresa all’interno di un discorso sulle pratiche artistiche, poco o nulla aperto al conf...

The essay reconsiders Wolfgang Iser’s phenomenology of reading, taken as a possible non reductionist answer to the neuroscientific theories of literature. By emphasizing the aesthetic nature of reading, thanks also to Hans Robert Jauss’ contribution, the idea of a ‘reader’s imagination’ emerges here, as a specific and unique power which allows not only the access to the world of the literary text, but opens also new spheres for the understanding and exploration of the real world. In shorts, it is concerned (...) with the constitution of a special cognitive-emotional pattern, which depends on the building of what Iser considers as the reader’s «artificial habitats», through the interaction with the text. (shrink)

Nel caso di riedizione di opera ormai classica, normalmente le ragioni che hanno spinto l’autore a riproporne o rivederne l’impianto sono proposte nella nuova prefazione o in introduzione: non è facile, invece, imbattersi – anche all’interno del corpo del testo vero e proprio - nella esplicita confessione del travaglio teorico all’origine del ripensamento, della rielaborazione e della revi­sione delle proprie posizioni interpretative. È quello che accade affrontando la lettura della recente t...

Tracciare una via verso Parmenide è quanto esplicitamente si propone la ri­cerca di Atwood Wilkinson: più esattamente un tentativo di « ascoltare di nuovo la sapienza dei nostri primi testi filosofici » (p. 7). Quella del poeta-filosofo di Elea, infatti, è opera della quale troppo spesso le letture metafisiche e analitiche di­menticano la peculiare collocazione tra la cultura orale della antica tradizione poetica e la allora relativamente recente pratica della scrittura: da quella tradi­zione...

This report is an attempt to reread the event of Revelation in view of DV 8: «Ecclesia, volventibus saeculis, ad plenitudinem divinae veritatis iugiter tendit, donec in ipsa consummentur verba Dei». The text aims at clarifying the eschatological character of Revelation, raising however a theological problem of great importance: if and in what measure is it possible to think of Revelation as a never concluded process, if the theological tradition asserts that Revelation is concluded with the death of the last (...) Apostle and Dei Verbum speaks of Christ as the fullness of Revelation? The eschatological character of Revelation is investigated in the light of the dynamism of the Tradition, in particular of DV 8, which gives indications of great interest to resolve the matter of the persistence of Revelation in the time of the Church. The report affirms that the Tradition does not limit itself to the understanding of the revealed fact, but it points out the participation of the Church in the dynamism of Revelation itself. The conclusion is reached by means of a description of the constitutive relationship between Christian experience and knowledge - described in Dei Verbum as intima spiritualium rerum quam experiuntur intelligentia - which has it most clear and most pertinent expression in the sensus fidei. (shrink)

The article considers the nature of series as a narrative, focusing especially on its chronotope, i.e. its spatiotemporal coordinates. The concept of chronotope can be applied at at least two different levels of the interpretation of a narrative: the real world of reception and the expressive form of narration. The impact of series entails both aspects. It is for this reason that series, once on television then on the internet, represented a revolutionary turn in the modern experience of storytelling. Series (...) are therefore bound to the progressive spread of a new form of sociality known as a digital “total mobilisation”. Since the era of TV series up to the emergence of web series, seriality has been able to regulate the increase of interaction in the use of visual devices. Series play the role of a dietetical regulator, which designs the spectators’ attention. An artistic, i.e. experimental, exploitation of this new form of storytelling is possible when one considers the emergence of a new narrative genre, which we propose to call the “short form”. (shrink)